Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

• Ketoconazole, itraconazole (used to manage fungal infection)
• Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
• Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
• Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
• Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

A high-fat meal, taking a dose over a high-fat meal, or positions for a meal at a higher rate of intake may reduce the interaction. It may be necessary to adjust the dose as advised by your doctor.Cialis may also interact with other medications, such as Stendra, tricyclic antidepressants, blood pressure medication,etc., and these should be avoided while using Cialis. Do not use Cialis if you are taking any type of medication for erectile dysfunction or the use of any type of corticosteroid in your treatment for arthritis.ekBlue® is a prescription medication used to treat erectile dysfunction. It may also interact with other medications, such as Stendra, tricyclic antidepressants, blood pressure medication,etc., alprostadil, certain antifungal medications, antacids, or high-fat foods, as advised by your doctor.Cialis and nitrates can affect the blood flow to the penis, which may increase or decrease with these medications. Do not take Cialis or nitrates with any combination of these medications.

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What is Tadalafil (Tadalafil)?

Tadalafil is the brand name for the prescription medication Cialis, also known astadalafil

Tadalafil is a medication used to treat erectile dysfunction (ED) in men. ED is the inability to achieve or maintain a hard, erect penis suitable for sexual activity.

ED is the inability to obtain or maintain erections for sexual activity. ED is the inability to maintain a hard erect penis suitable for sexual activity.

The main indications for taking Tadalafil includeerectioningerectile dysfunctionimpotence,trouble achieving or maintaining a erection

How Tadalafil works

Tadalafil works bysuppressing the enzyme phosphodiesterase type 5 (PDE5), which is involved in the control of blood flow to the penis.

PDE5 is an enzyme that breaks down certain chemicals in the body (including chemicals that cause erections) that are responsible for erections. PDE5 is responsible for breaking down chemicals that cause erections in men.

Tadalafil is the main ingredient contained in Cialis and is used totreat erectile dysfunctionin men. This medicine can be used to treat(impotence where erections do not result in a hard, erect penis suitable for sexual activity) in men.

Side effects

Most people who take Tadalafil do not have any side effects from it. However, some men may experiencemuscle painheadache, andback pain

If you experience severe or persistent side effects, talk to your doctor.

How to take Tadalafil

Always follow the instructions and directions provided by your doctor, and never take Tadalafilorany medicine that contains itthat is not available in the marketplace. The dosage of Tadalafil depends on the severity of your ED and the severity of your underlying medical condition. Your doctor will determine the appropriate dosage of Tadalafil for you based on your age, health condition, and response to treatment.

Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

• Headache
• Indigestion
• Heartburn
• Upset stomach
• Gas
• Nausea
• Flushing

More severe side effects include:

• Painful erections or erections that last longer than 4 hours
• Sudden loss of vision
• Sudden loss of hearing
• Ringing in the ears
• Chest pain
• Shortness of breath
• Painful urination
• Increased urination frequency
• Fainting
• Dizziness
• Skin rash
• Hives
• Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

Read more about Cialis.

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• Muscle aches
• Back pain

As with all prescription medications, inform your doctor if you experience any serious adverse reactions to Cialis. These can include:

Take the medication as directed by your doctor. () () ()Stomach problems (such as ulcers or bleeding that is caused by the introduction of a new drug) ()

As with all prescription medications, inform your doctor if you experience any changes in your symptoms or if you notice any new or additional side effects.

As with all prescription medications, inform your doctor if you experience any allergic reactions to Cialis or other drugs if you are pregnant or intend to become pregnant, or if you have any kidney or liver problems.

As with all prescription medications, inform your doctor if you are a woman or a child under the age of 18. Cialis can interact with the following:

• High blood pressure medication
• Amlodipine
• Nitrates
• HIV protease inhibitors
• Alpha-blockers
• Rifampin

As with all prescription medications, inform your doctor if you are a man or a woman under the age of 18.

• Ritonavir
• Sildenafil
• Mycophenolate mofetil

As with all prescription medications, ensure your doctor is aware of any medical conditions you have been diagnosed with before starting Cialis. Mycophenolate mofetil is a medication that works by blocking your body’s ability to produce a fertilized egg.

Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

• Headache
• Indigestion
• Heartburn
• Upset stomach
• Gas
• Nausea
• Flushing

More severe side effects include:

• Painful erections or erections that last longer than 4 hours
• Sudden loss of vision
• Sudden loss of hearing
• Ringing in the ears
• Chest pain
• Shortness of breath
• Painful urination
• Increased urination frequency
• Fainting
• Dizziness
• Skin rash
• Hives
• Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

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Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

• Headache
• Indigestion
• Heartburn
• Upset stomach
• Gas
• Nausea
• Flushing

More severe side effects include:

• Painful erections or erections that last longer than 4 hours
• Sudden loss of vision
• Sudden loss of hearing
• Ringing in the ears
• Chest pain
• Shortness of breath
• Painful urination
• Increased urination frequency
• Fainting
• Dizziness
• Skin rash
• Hives
• Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

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As with most medications, Cialis can cause a dangerous drop in blood pressure. This can be a potential side effect of this drug.

As with many medications, Cialis can cause a dangerous drop in blood pressure.